Scientists have created genetically modified mouse which manifests remarkable physical behaviour. It can run 6 kms at a speed of of 20 metres per minute for five hours, eats 60% more than normal mouse, does not put on weight, enjoys an active sex life to an old age, and lives longer. The mouse produces very little lactic acid, which causes muscle cramps, a feature associated with endurance athletes. All in all a very strong mouse. The phosphonenolpyruvate carboxykinase (PEPCK-C) is an enzyme of gluconeogenesis pathway. The formation of glucose from nonhexose precursors is gluconeogenesis. The enzyme PEPCK-C catalyzes the conversion of oxaloacetate to phosphoenolpyruvate using GTP as the phosphate donor. The transgenic mice carrying the gene for PEPCK-C, under the control of skeletal actin gene promoter, were created. The transformed mice showed a highly increased production of this enzyme. This led to the enhancement of physical and behavioral characters of the mice. Professor Hanson, who led the team of researchers responsible for the creation of the “mighty mouse”, said, “They are metabolically similar to Lance Armstrong biking up the Pyrenees. They utilise mainly fatty acids for energy and produce very little lactic acid. They are not eating or drinking and yet they can run for four or five hours. They are 10 times more active than ordinary mice in their home cage. They also live longer – up to three years of age – and are reproductively active for almost three years. In short, they are remarkable animals.”On the possibilities of trying the same in humans he said, “We humans have exactly the same gene. But this is not something that you’d do to a human. It’s completely wrong. We do not think that this mouse model is an appropriate model for human gene therapy. It is currently not possible to introduce genes into the skeletal muscles of humans and it would not be ethical to even try.” Read the full story here.
via: The Independent